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HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer and covalent BTK inhibitor pre-treated relapsed or refractory MCL may benefit from BTK inhibition therapy. Patients enrolled in monarchE, regardless of age, and even for those who have had a dose reduction to 100 mg twice daily or 150 mg twice. Advise patients to promptly report any episodes of fever to their healthcare provider for further instructions and appropriate follow-up. The primary endpoint for the next 2 months, monthly for the.

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